Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors
Abstract Background Prostate cancer metastasizes to regional lymph nodes T-Shirts and distant sites but the roles of lymphatic and hematogenous pathways in metastasis are not fully understood.Methods We studied the roles of VEGF-C and VEGFR3 in prostate cancer metastasis by blocking VEGFR3 using intravenous adenovirus-delivered VEGFR3-Ig fusion pro